 |
|
|
ADD TO CART
|
| Product ID | JR8-N1156 |
| Product Name | Aristolochic acid A (New Product) |
| CAS # | 313-67-7 |
| Structure |  |
| Chemical Purity | 98% (HPLC) | | Appearance | Yellow powder |
| Price | $128/100mg, 500mg, 1g, 5g |
| Comments | Aristolochic acid is an alkaloid originally isolated from A. radix that inhibits inflammatory phospholipase A2 (PLA2) activity (IC50 = 40 µM in human neutrophils).1 It inhibits human synovial fluid PLA2-induced edema in a dose-dependent manner in vivo which positively correlates with in vitro inhibition of PLA2.2 Aristolochic acid inhibits hemolytic activity of PLA2s TFV PL-X, TFV PL-Ia, and TFV PL-Ib from T. flavoviridis venom (IC50s = 4.6, 4.0, and 3.9 µM, respectively) but enhances the edema-inducing activity of TFV PL-Ia and TFV PL-Ib.3 Aristolochic acid exposure is also associated with progressive interstitial fibrosing nephropathy and upper urinary tract urothelial carcinomas. |
| Availability |
PLEASE ASK US |
|
|
|
|
|