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| Product ID | JR8-N0200 |
| Product Name | Celastrol (New Product) |
| CAS # | 34157-83-0 |
| Structure |  |
| Chemical Purity | 98% | | Appearance | Red solid |
| Price | $398/1g, $918/5g |
| Comments | >100g in stock.
Cell-permeable. An Antioxidant, anti-inflammatory and immunosuppressive agent. Suppresses LPS-induced cytokine release in macrophages and monocytes (IC₅₀ = 40 nM for IL-1â and IL-1á, 80 nM for IL-6, 110 nM for prostaglandin E2 and 210 nM for IL-8 and TNF-á). Suppresses nitric oxide (NO) production (IC₅₀ = 230 nM) and LPS-induced NF-ęB activation (IC₅₀ = 270 nM). Inhibits chymotrypsin-like activity of 20S proteasome (IC₅₀ = 2.5 µM) and lipid peroxidation induced by ADP and Fe˛⁺ in rat liver mitochondria (IC₅₀ = 7 µM). |
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