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| Product ID | JR8-N0120 |
| Product Name | Jatrorrhizine (New Product) |
| CAS # | 3621-38-3 |
| Structure |  |
| Chemical Purity | 98% | | Appearance | Yellow to orange powder |
| Price | $68/20mg, $518/100mg, $918/500mg $1480/1g |
| Comments | Product is in stock.
Jatrorrhizine is an alkaloid compound originally isolated from Corydalis and Coptydis tubers that exhibits anticancer, neuroprotective, anti-parasitic, antioxidative, and gastrointestinal modulatory activities. Jatrorrhizine increases expression of p21 and p27, inducing G0/G1 phase cell cycle arrest and inhibiting proliferation in melanoma cells. In neurons, jatrorrhizine suppresses amyloid- (A )-induced increases in caspase 3 activation and cytochrome c release, preventing neurotoxicity. Jatrorrhizine also displays anti-parasitic benefit against Plasmodium, Leishmania, and Trypanosoma. In neurons, this compound inhibits H202-induced decreases in superoxide dismutase (SOD) and heme oxygenase 1 (HO-1) and increases in lactate dehydrogenase (LDH), malondialdehyde (MDA), and ROS. Jatrorrhizine increases gastric emptying and intestinal transit speeds in animal models of postoperative ileus. Additionally, jatrorrhizine inhibits acetylcholinesterase (AChE). |
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