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| Product ID | JR6-ZK3040 |
| Product Name | Cabazitaxel |
| CAS # | 183133-96-2 |
| Structure |  |
| Chemical Purity | 98% | | Appearance | White powder |
| Price | $128/100mg, $328/1g, $3980/20g |
| Comments | In stock. Cabazitaxel is a semi-synthetic derivative of toxal, a natural taxoid microtubule inhibitor. Cabazitaxel has been shown to have antitumor activity in vitro, and while it has a lower affinity for the ATP-dependent efflux pump, P-glycoprotein 1 (P-gp) relative to toxal or docetaxel, it has shown greater ability to penetrate the blood-brain barrier than either. In mice and rat models, uptake of cabazitaxel has been shown to increase at concentrations above 11 ìM and saturation has been seen at 13 ìM. This seems to suggest that P-gp may be essential to transport cabazitaxel across the blood-brain barrier at specific threshold concentrations. |
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